منابع مشابه
The adult epicardium: realizing the potential for neovascular therapy.
From the first description of its origins by the PolishGerman anatomist Robert Remak in 1855, through to latter day studies into its role in establishing the coronary vasculature (reviewed in1), the embryological epicardium (outermost mesothelial epithelial layer that envelops the developing heart) has intrigued embryologists, cell biologists, and cardiologists alike. The adult epicardium, on t...
متن کاملThe Epicardium in the Embryonic and Adult Zebrafish
The epicardium is the mesothelial outer layer of the vertebrate heart. It plays an important role during cardiac development by, among other functions, nourishing the underlying myocardium, contributing to cardiac fibroblasts and giving rise to the coronary vasculature. The epicardium also exerts key functions during injury responses in the adult and contributes to cardiac repair. In this artic...
متن کاملDynamic haematopoietic cell contribution to the developing and adult epicardium
The epicardium is a cellular source with the potential to reconstitute lost cardiovascular tissue following myocardial infarction. Here we show that the adult epicardium contains a population of CD45+ haematopoietic cells (HCs), which are located proximal to coronary vessels and encased by extracellular matrix (ECM). This complex tertiary structure is established during the regenerative window ...
متن کاملThymosin beta4 induces epicardium-derived neovascularization in the adult heart.
The inability of the human heart to effectively repair itself after acute ischaemic injury has driven the search for efficacious means of promoting cardiac regenerative growth. Central to this has been the emergence of cell-based strategies to stimulate and augment both myocardial regeneration and neovascularization. Autologous cell transplantation of a variety of adult progenitor cells has bee...
متن کاملHeterogeneity in Pkp2-Containing Junctions in the Adult Epicardium
The epicardium, a thin layer of mesothelial cells that encapsulate the heart, is a major source of cardiac fibroblasts during development as a result of epithelial to mesenchymal transition (EMT). EMT requires the loss of cell-to-cell adhesion and conditions and/or diseases that destabilize cellular junctions. Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited disorder assoc...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2008
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.108.165191